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Opicapone may be favored over entacapone since its pharmacokinetics permits for once daily dosing and has shown to be non-inferior to the efficacy of entacapone. Total ON time without troublesome dyskinesia was greater with opicapone 101 minutes and entacapone 93 min-. Ongentys Opicapone Capsules Why Ongentys To clarify how easily can entacapone ENT be switched to opicapone OPC in levodopa-treated patients with Parkinsons disease PD and motor-fluctuations. Entacapone vs opicapone . The safety and efficacy of opicapone were established in the aforementioned randomized double-blind placebo-controlled phase 3 clinical trials. Treatment with opicapone 50 mg in comparison with entacapone led to a greater increase in the proportion of patients who woke up in ON-status and a greater decrease in time-to-ON from first morning levodopa intake the researchers concluded. The figure for entacapone was 58 p007 vs pla-cebo. One hour after administration COMT inhibition was 99 with opicap