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In August 2017 the US FDA approved CPX-351 vyxeos a liposomal formulation of cytarabine and daunorubicin at a fixed 51 molar ratio for the treatment of adults with newly diagnosed AML with myelodysplasia-related changes AML-MRC and therapy-related AML t-AML. Histone deacetylase inhibitors may synergize with hypomethylating agents. Interpretation Of Clinical Endpoints In Trials Of Acute Myeloid Leukemia Sciencedirect The primary end point was overall survival. Vyxeos clinical trial . In this open-label randomized phase III trial 309 patients age 60 to 75 years with newly diagnosed high-risksAML received one to two induction cycles of CPX-351 or 73 followed by consolidation therapy with a similar regimen. We report final results from a randomized open-label study of first-line CPX-351 in patients with high. Older patients with secondary AML have poor outcomes following first-line cytarabine and anthracycline-based treatment. The complete response rate was 38 in the Vyxeos-tr