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IDH12 is mutated in 7080 of lower-grade gliomas and the majority of secondary glioblastomas. Isocitrate dehydrogenase 1 and 2 mutations mIDH12 occur in solid tumors including glioma and result in production of the oncometabolite 2-hydroxyglutarate 2-HG promoting tumorigenesis. Isocitrate Dehydrogenase Mutant Glioma Evolving Clinical And Therapeutic Implications Miller 2017 Cancer Wiley Online Library HIF-1α levels were higher in human gliomas harboring an IDH1 mutation than in tumors without a mutation. Idh inhibitor glioma . When mutated IDH creates a molecule that alters the. For example glutaminase blockade through bis-2-5-phenylacetamide-134-thiadiazol-2-ylethyl sulfide inhibits glutamine metabolism and suppresses IDH1-mutated glioma. AG-881 is an oral potent brain-penetrant inhibitor of mIDH12 that reduces 2-HG by up to 98 in glioma models. IDH1 and IDH2 mutations occur in various cancers including gliomas and leukemias Losman and Kaelin 2013. With vorasidenib the fir