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Because of the small subset of patients not on RAAS inhibitors and the potential confounding effect of other diuretic treatment post-hoc analyses are unlikely to be able to. EMPA-REG OUTCOME is an international prospective placebo-controlled clinical trial investigating the cardiovascular outcomes of empagliflozin an inhibitor of sodium-glucose cotransporters type 2 SGLT2 in patients with type 2 diabetes mellitus and known cardiovascular disease. Empagliflozin Cardiovascular Outcomes And Mortality In Type 2 Diabetes Nejm In the EMPA-REG OUTCOME trial we exam-ined the effects of empagliflozin as compared with placebo on cardiovascular morbidity and mortality in patients with type 2 diabetes at high risk for. Empa reg trial . Read our disclaimer for details. In the EMPA-REG OUTCOME trial BI 10773 Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients in patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease in comparison with