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POMALYST pomalidomide is a thalidomide analogue indicated in combination with dexamethasone for adult patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy. POMALYSTpomalidomide is a thalidomide analogue indicated in combination with dexamethasone for adult patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy. Mechanism Of Action Pomalyst Pomalidomide There is a pregnancy exposure registry that monitors pregnancy outcomes in females exposed to Pomalyst during pregnancy as well as female partners of male patients who are exposed to Pomalyst. Pomalyst mechanism of action . In combination with dexamethasone for patients with multiple myeloma MM who