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POMALYST pomalidomide is a thalidomide analogue indicated in combination with dexamethasone for adult patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy. POMALYSTpomalidomide is a thalidomide analogue indicated in combination with dexamethasone for adult patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy.
Mechanism Of Action Pomalyst Pomalidomide
There is a pregnancy exposure registry that monitors pregnancy outcomes in females exposed to Pomalyst during pregnancy as well as female partners of male patients who are exposed to Pomalyst.
Pomalyst mechanism of action. In combination with dexamethasone for patients with multiple myeloma MM who have received at least two prior therapies including lenalidomide and a proteasome. The chemical name is RS-4-Amino-2- 26-dioxopiperidin-3-yl-isoindoline-13-dione and it has the following chemical structure. Mechanism of Action.
Pomalyst is supplied as a capsule for oral administration. Regimen for POMALYST with dexamethasone andor bortezomib is summarized in Table 1. Pomalidomide an analogue of thalidomide is an immunomodulatory agent with antineoplastic activity.
Mechanism of action Promalidomide is an immunomodulatory agent with antineoplastic activity. Based on the mechanism of action and findings from animal studies Pomalyst can cause embryo-fetal harm when administered to a pregnant female and is contraindicated during pregnancy. POMALYST is a thalidomide analogue indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and.
Pomalidomide an analogue of thalidomide is an immunomodulatory agent with antineoplastic activity. It is shown to inhibit the proliferation and induce apoptosis of various tumour cells. Down-modulates cell surface adhesion molecules involved in leukocyte migration.
Although its exact mechanism of action has yet to be fully elucidated pomalidomide appears to inhibit TNF-alpha production enhance the activity of T cells and natural killer NK cells and enhance antibody-dependent cellular cytotoxicity ADCC. View Pomalyst description for details of the chemical structure and excipients inactive components. POMALYST is an immunomodulatory antineoplastic agent.
Pomalidomide is a yellow solid powder. POMALYST is a thalidomide analogue indicated for the treatment of adult patients. Dosage Regimen for Patients Treated with POMALYST for Multiple Myeloma Drug Dose Regimen POMALYST in combination with bortezomib and dexamethasone POMALYST 4 mg orally once daily Days 1-14 for each 21-day cycle until disease progression.
The empirical formula for pomalidomide is C 13 H 11 N 3 O 4 and the gram molecular weight is 27324. In in vitro cellular assays pomalidomide inhibited proliferation and induced apoptosis of hematopoietic tumor cells. It may act by inhibiting the growth of new blood vessels angiogenesis in tumors enhancing the status of the immune system or decreasing cytokine and growth factor production.
In in vitro cellular assays pomalidomide inhibited proliferation and induced apoptosis of hematopoietic tumor cells. It inhibits proliferation and induced apoptosis of hematopoietic tumor cells Additionally it enhances T-cell and natural killer cell-mediated immunity and suppresses production of TNF-alpha and interleukin-6. Action View Pomalyst mechanism of action for pharmacodynamics and pharmacokinetics details.
Pomalidomide an analogue of thalidomide is an immunomodulatory agent with antineoplastic activity. Pomalidomide has been shown in vitro to inhibit the proliferation of. Mechanism of Action Thalidomide analog that elicits immunomodulatory and antineoplastic activity.
Pomalysts exact mechanism of action on cancer cells is not clear. The mechanism of action of pomalidomide is not fully understood.
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